Preclinical safety evaluation of biopharmaceuticals
245,00 $

Preclinical safety evaluation of biopharmaceuticals

JOY A. CAVAGNARO


Preclinical safety evaluation of biopharmaceuticals

JOY A. CAVAGNARO

245,00 $ 245,00 $
Régulier: 245,00 $
Rabais: 0,00 $ (0%)
Livre numérique non disponible
Résumé
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies."
—From the Afterword by Anthony D. Dayan

Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials:
  • Includes an overview of biopharmaceuticals with information on regulation and methods of production
  • Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan
  • Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals
  • Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals
  • Covers transitioning from preclinical development to clinical trials
This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

Détails
Titre
Preclinical safety evaluation of biopharmaceuticals
Prix
245,00 $
Sujet
Format Poche
Non
Langue
Français/French
Date de publication
2013-03-07
ISBN
9780470292532
Code Interne
2174190
Numéro de produit
2174190
Format numérique
pdf
Protection
Adobe DRM
Entrepôt Numérique
NUMILOG

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