Study of the calcium regulation mechanism of tcr activation using nanodisc and nmr technologies
150,36 $

Study of the calcium regulation mechanism of tcr activation using nanodisc and nmr technologies

YUNCHEN BI


Study of the calcium regulation mechanism of tcr activation using nanodisc and nmr technologies

YUNCHEN BI

150,36 $ 150,36 $
Régulier: 150,36 $
Rabais: 0,00 $ (0%)
Livre numérique non disponible
Résumé

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.


Détails
Titre
Study of the calcium regulation mechanism of tcr activation using nanodisc and nmr technologies
Auteur
Prix
150,36 $
Sujet
Format Poche
Non
Langue
Français/French
Date de publication
2017-06-20
ISBN
9783662546185
Code Interne
2270650
Numéro de produit
2270650
Format numérique
pdf
Disponibilité
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Protection
Adobe DRM
Entrepôt Numérique
NUMILOG

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